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Amantadine interferes with influenza virus at the stage of

  • A.uncoating
  • B.attachment
  • C.assembly
  • D.budding

Answer: A

The drug blocks the viral ion channel needed to acidify the interior of the endosome and release the genome, so the particle is taken up but never uncoats. It is a good illustration of a step that looks minor being an effective point of attack.

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