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Discussion

The principal disadvantage of a live attenuated vaccine is

  • A.that it requires no testing before use
  • B.that it contains no viral material
  • C.the risk of reversion to a pathogenic form
  • D.that it cannot produce antibodies

Answer: C

A live vaccine strain has been weakened by laboratory manipulation, and a weakened organism may mutate back toward virulence. Recombinant methods that delete the regions likely to revert are one way of reducing that risk.

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