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Inclusions seen in an infected cell under the light microscope are useful because they

  • A.indicate viral growth without resolving particles
  • B.are the virions themselves, individually visible
  • C.prove the cell is uninfected
  • D.are always found in uninfected cells too

Answer: A

Correct answer: indicate viral growth without resolving particles

A virion is far below the resolving power of a light microscope, but the aggregates of viral protein and nucleic acid that accumulate at sites of replication are large enough to be seen and stained. The inclusion is therefore evidence of infection rather than a view of the virus, and its position and staining can be characteristic - Negri bodies in rabies being the classic example.

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