Discussion
The first step in the replication of a virus with the reverse transcriptase deals with the synthesis of
Answer: C
The first step is synthesis of a complementary strand of DNA.
In a retrovirus such as HIV, reverse transcriptase first uses the viral RNA genome as a template to make a complementary DNA strand, giving an RNA-DNA hybrid. Its RNase H activity then degrades the RNA, and the enzyme makes the second DNA strand, producing double-stranded DNA that is integrated into the host genome.
Double-stranded DNA is the end product of reverse transcription, not its first step, and making a complementary RNA strand or double-stranded RNA is RNA-dependent RNA synthesis, which reverse transcriptase does not perform.
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