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The concentration of infectious plaque forming units (pfu) per volume of fluid is known as the :

  • A.Virulence
  • B.Infectivity
  • C.Titer
  • D.Pathogenicity

Answer: C

It is known as the titer.

In a plaque assay, serial dilutions of a virus sample are spread on a lawn of host cells or bacteria. Each infectious particle produces a clear zone, a plaque. Counting the plaques at a suitable dilution and multiplying by the dilution factor gives the number of plaque-forming units per millilitre, the titer of the stock, for example 2 × 109 pfu/ml.

Virulence and pathogenicity describe how much disease a virus causes, not how many particles are present. Infectivity is the ability to establish infection, a property of the virus rather than a count per volume.

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