Discussion
The vitamin which plays an important role in conversion of proline to hydroxyproline in building the appropriate collagen protein is :
Answer: C
The vitamin is Vitamin C (ascorbic acid).
Prolyl hydroxylase converts proline residues in procollagen to hydroxyproline, using iron, oxygen and 2-oxoglutarate. Ascorbate keeps the enzyme's iron in the reduced ferrous state. Hydroxyproline is needed for hydrogen bonds that stabilise the collagen triple helix, so in vitamin C deficiency collagen is weak and the result is scurvy: bleeding gums, poor wound healing and fragile blood vessels.
Vitamin A works in vision and epithelial differentiation, the B vitamins as coenzymes in energy metabolism, and vitamin D in calcium absorption; none is the cofactor for proline hydroxylation.
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