Discussion
Supplemental nicotinamide or its analogue niacin relieves the dietary deficiency disease known as :
Answer: D
The disease is pellagra.
Pellagra is caused by deficiency of niacin (vitamin B3), the precursor of NAD and NADP. Its features are the 'three Ds': dermatitis on sun-exposed skin, diarrhoea and dementia. It occurred where maize, poor in available niacin and tryptophan, was the staple food, and nicotinamide or nicotinic acid cures it.
Pernicious anaemia is caused by vitamin B12 deficiency (through lack of intrinsic factor), megaloblastic anaemia by B12 or folate deficiency, and marasmus by overall energy and protein starvation.
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