Machine-translated by Google. Questions are authored in English.
Top

HPSC Polytechnic Lecturer 2022: Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021)

  • Paper code: Advt. No. 11/2021
  • Language: English
  • 16 pages
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 1 of 16
Page 1 of 16
Text of page 1
DO NOT OPEN THE SEAL UNTIL INSTRUCTED TO DO SO

                                                        Question Booklet No.

                                      QUESTION BOOKLET
                                           PHARMACY
                                                                                        Booklet Series



                                                                                              A
Roll No.

(Enter your Roll number in the above space)

Time Allowed : 2 Hours                                                           Maximum Marks : 100

                             INSTRUCTIONS FOR CANDIDATES
1.   IMMEDIATELY AFTER THE COMMENCEMENT OF THE EXAMINATION, YOU SHOULD CHECK THAT
     THIS QUESTION BOOKLET DOES NOT HAVE ANY UNPRINTED OR TORN OR MISSING PAGES OR
     QUESTIONS ETC. IF SO, GET IT REPLACED BY A COMPLETE QUESTION BOOKLET.
2.   Please note that it is the candidate’s responsibility to encode and fill in the Roll Number and
     Question Booklet Series Code A, B, C or D carefully and without any omission or discrepancy at
     the appropriate places in the OMR Answer Sheet. Any omission/discrepancy will render the
     OMR Answer Sheet liable for rejection.
3.   This Question Booklet contains 100 questions. Each question is printed in English only. Each
     question comprises four responses (answers). You will select the response which you want to
     mark on the OMR Answer Sheet. In case you feel that there is more than one correct response,
     mark the response which you consider the best. In any case, choose ONLY ONE response for
     each question.
4.   You have to mark all your responses ONLY on the separate OMR Answer Sheet provided. See
     Instructions at the backside of the OMR Answer Sheet.
5.   All questions carry equal marks.
6.   Before you proceed to mark in the OMR Answer Sheet the response to various questions in the
     Question Booklet, you have to fill in some particulars in the OMR Answer Sheet as per
     instructions mentioned on the OMR Answer Sheet.
7.   After you have completed filling in all your responses on the OMR Answer Sheet and the
     examination has concluded, you should hand over to the Invigilator only the OMR Answer
     Sheet. You are permitted to take away with you the Question Booklet, along with candidate’s
     copy of OMR Answer Sheet.
8.   Sheets for rough work are appended in the Question Booklet at the end.
9.   Penalty for wrong answers :
     THERE WILL BE PENALTY FOR WRONG ANSWERS MARKED BY A CANDIDATE AS UNDER.
       (i) There are four alternatives for the answer to every question. For each question for which
           a wrong answer has been given by the candidate, 0.25 mark assigned to that question will
           be deducted as penalty.
      (ii) If a candidate gives more than one answer, it will be treated as a wrong answer even if one
           of the given answers happens to be correct and there will be same penalty as above to that
           question.
     (iii) If a question is left blank, i.e., no answer is given by the candidate, there will be no penalty
           for that question.

              DO NOT OPEN THE SEAL UNTIL INSTRUCTED TO DO SO
Pharmacy/17-A
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 2 of 16
Page 2 of 16
Text of page 2
1. The simplest phenols are liquids or            5. If 5·6 g KOH is    dissolved   in
     low-melting solids and have high                  distilled water and the volume is
     boiling points due to                             made up to 100 ml with distilled
     [A] covalent linkage                              water, we get a

     [B] hydrogen bonding                              [A] 0·1 N solution
     [C] glycosidic bonding                            [B] 1 N solution
     [D] electrophilic linkage                         [C] 0·01 N solution

  2. IR spectra of a sample shows                      [D] 0·01 M solution
     absorption frequencies at 1740 cm–1
     and 3600 cm–1. This indicates the              6. Which of     the following is the
     presence of                                       increasing   order of elution of
     [A] an amide and carboxylic acid                  solvents?
         in the sample respectively
                                                       [A] Toluene < Cyclohexane <
     [B] a carbonyl group and phenolic                             Acetone < Acetonitrile
         OH in the sample respectively
                                                       [B] Cyclohexane < Acetone <
     [C] an amide and substituted                                  Toluene < Acetonitrile
         benzene     in the sample
         respectively                                  [C] Cyclohexane < Acetonitrile <
                                                                      Toluene < Acetone
     [D] an anhydride and carboxylic
         acid in the sample respectively               [D] Cyclohexane < Toluene <
                                                                   Acetone < Acetonitrile
  3. The IUPAC name of paracetamol is
     [A] N-(4-hydroxyacetyl)        acetamide       7. How     many     aldohexoses are
     [B] N-(4-phenyl) acetamide                        possible, if there are 4 chiral
                                                       centres in the compound?
     [C] N-(4-hydroxyphenyl)
                      phenylacetamide                  [A] 4
     [D] N-(4-hydroxyphenyl) acetamide                 [B] 8

  4. Match the common developing                       [C] 16
     reagents in TLC with their respective             [D] 24
     groups they are used to identify :
Developing reagent             Group                8. How to prepare 0·1M solution of
  (i) Iodine vapour        P. Alkaloids                HCl?
 (ii) 1% ninhydrin         Q. Organic bases            [A] Dilute 85 ml of hydrochloric
 (iii) 2,4-dinitrophenyl R. Amino acids                    acid to 1000 ml with water
       hydrazine                                       [B] Dilute 0·85 ml of hydrochloric
 (iv) Dragendorff          S. Aldehydes                    acid to 1000 ml with water
     [A] (i)–P, (ii)–Q, (iii)–R, (iv)–S                [C] Dilute 8·5 ml of hydrochloric
     [B] (i)–Q, (ii)–R, (iii)–S, (iv)–P                    acid to 100 ml with water
     [C] (i)–P, (ii)–R, (iii)–S, (iv)–Q                [D] Dilute 8·5 ml of hydrochloric
     [D] (i)–Q, (ii)–P, (iii)–R, (iv)–S                    acid to 1000 ml with water

Pharmacy/17-A                                   2
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 3 of 16
Page 3 of 16
Text of page 3
9. KCl reacts with AgNO3 to form                       12. Select a water-soluble synthetic
     precipitates and conductance of                         polymer  used    commonly     in
     the solution remains same. This is                      pharmaceutics.
     known as                                                [A] Carrageenan

     [A] conductometric titration                            [B] Chitosan

     [B] oxidation-reduction reaction                        [C] Polyacrylamide
                                                             [D] Sodium starch glycolate
     [C] precipitation           conductometric
         titration
                                                         13. Select the correct assertion from
     [D]   acid base titration                               the following.
                                                             [A] Hydrophilic colloids are stable
10. Read the following statements                                and reversible
    regarding extraction methods :
                                                             [B] Hydrophobic colloids are stable
     (i) Maceration is used for extraction                       and reversible
         from hard and tough drugs
                                                             [C] Hydrophilic   colloids     show
     (ii) Maceration is used for extraction                      strong Tyndall effect
          from expensive drugs                               [D] Hydrophobic   colloids     show
                                                                 weak Tyndall effect
    (iii) Maceration is used for extraction
          from gummy substances
                                                         14. Which of the following is not true
    (iv) Percolation is used for extraction                  for dendrimers?
         from hard and tough drugs
                                                             [A] Dendrimers are nano-sized
     Which of the following statements                                             molecules
     are correct ?
                                                             [B] Dendrimers are radially
     [A] Statements (i) and (ii) are incorrect                           symmetric molecules

     [B] Statements (i) and (ii) are correct                 [C] Dendrimers are
                                                                              heterogeneous
     [C] Statements      (iii)    and   (iv)   are
                                                             [D] Dendrimers are hyperbranched
         incorrect
                                                                                    molecules
     [D] All Statements are correct
                                                         15. Different    types    of dissolution
                                                             apparatus are defined in the
11. Bloom strength is a measure of
                                                             United States Pharmacopeia (USP ).
    cohesive strength and is used to
                                                             Which of the following is not
    check the quality of
                                                             official in the USP ?
     [A] lactose                                             [A] Basket type
     [B] gelatin                                             [B] Flow-through cell
     [C] agaropectin                                         [C] Paddle over disc

     [D] chitosan                                            [D] Reciprocating column
Pharmacy/17-A                                        3                                     [ P.T.O.
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 4 of 16
Page 4 of 16
Text of page 4
16. Which of the following categories               19. A sample of crude drug shows no
    is    correct    according      to                  reaction in Borntrager’s test and
    Biopharmaceutics    Classification                  pink    colouration  in   modified
    System (BCS)?                                       Borntrager’s test. This shows the
                                                        presence of
     [A] Class I :
         High solubility, high permeability :           [A] anthraquinone O-glycosides
         generally moderately-absorbed                  [B] cardenolides
         compounds
                                                        [C] bufadienolides
     [B] Class II :
                                                        [D] anthraquinone C-glycosides
         Low solubility, high permeability :
         exhibits dissolution rate-limited
         absorption                                 20. The given figure shows the DRC of
                                                        4 drugs (i.e. A, B, C, D ). Which
     [C] Class III :                                    drug is most potent?
         Low solubility, low permeability :
         very poor oral bioavailability
     [D] Class IV :
         High solubility, low permeability :
         exhibits     permeability-limited
         absorption

17. Select the specific chemical test
    for the phytoconstituents from the
    following :
  Specific chemical test    Phytoconstituents
  (i) Murexide test         P. Rhein
  (ii) Borntrager test     Q. Glycyrrhizin
 (iiii) Froth formation     R. Atropine                 [A] Drug A is most potent and
                                                            most efficacious
 (iv) Mayer’s test          S. Caffeine
                                                        [B] Drug B is most potent and
     [A] (i)–S, (ii)–P, (iii)–Q, (iv)–R                     least efficacious
     [B] (i)–P, (ii)–Q, (iii)–R, (iv)–S                 [C] Drug C is most potent and
     [C] (i)–R, (ii)–P, (iii)–Q, (iv)–S                     most efficacious

     [D] (i)–S, (ii)–Q, (iii)–R, (iv)–P                 [D] Drug D is most potent and less
                                                            efficacious than A

18. If 0·8 ml of volatile oil is isolated
                                                    21. Which      route   for  regular
    from 50 g of fennel, this means yield
                                                        formulations cannot bypass the
    of volatile oil is
                                                        first-pass effect?
     [A] 1·6% v/w
                                                        [A] Sub-cutaneous
     [B] 1·6% v/v                                       [B] Oral
     [C] 1·6% w/v                                       [C] Sub-lingual
     [D] 1·6% w/w                                       [D] Buccal
Pharmacy/17-A                                   4
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 5 of 16
Page 5 of 16
Text of page 5
22. If a person has had corona virus               26. Classification of bacteria on the
    infection and has immunity, this is                basis of shapes does not include
    known as                                           which of the following?

     [A] natural immunity                               [A] Cyano

     [B] naturally      acquired      active            [B] Bacilli
         immunity
                                                        [C] Cocci
     [C] naturally      acquired     passive
         immunity
                                                        [D] Spirilla
     [D] artificially   stimulated    active
         immunity
                                                   27. By which method can the following
                                                       be sterilized in a tissue culture
23. High   plasma   protein          binding           laboratory?
    makes the drug to have
                                                   Lab component         Sterilization method
     [A] faster elimination
                                                    (i) Laboratory          P. Dry heat
     [B] prolonged action
                                                   (ii) Enzyme solution Q. Moist heat
     [C] faster distribution
                                                   (iii) Growth media      R. Micropore
     [D] faster metabolism                                                    filtration

24. Which of the following enhances                (iv) Glassware           S. Fumigation
    insulin secretion?
                                                        [A] (i)–P, (ii)–Q, (iii)–R, (iv)–S
     [A] Glimepiride
                                                        [B] (i)–S, (ii)–R, (iii)–Q, (iv)–P
     [B] Metformin
                                                        [C] (i)–Q, (ii)–S, (iii)–R, (iv)–P
     [C] Acarbose
                                                        [D] (i)–S, (ii)–P, (iii)–R, (iv)–Q
     [D] Bromocriptin

                                                   28. _____ is regarded as the ‘‘father’’ of
25. Which of the following is not a                    biotechnology.
    GMO?
                                                        [A] Toshio Murashighe
     [A] Dolly

     [B] Golden Rice                                    [B] Folke K Skoog

     [C] BT Brinjal                                     [C] Karole Ereky

     [D] CT Corn                                        [D] Gottlieb Haberlandt

Pharmacy/17-A                                  5                                             [ P.T.O.
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 6 of 16
Page 6 of 16
Text of page 6
29. For     in-vitro   cultivation    of       32. The     sequence   for pharmaco-
    microorganisms, which of         the           vigilance may be summarized by
    following is a micronutrient?
                                                   [A] detection of adverse event–
     [A] Nitrogen                                      separating signal from noise–
                                                       signal assessment–
     [B] Carbon                                        recommendation for action–
                                                       exchange of information
     [C] Copper
                                                   [B] separating signal from noise–
     [D] Phosphate                                     detection of adverse event–
                                                       signal assessment–
                                                       recommendation for action–
30. Which of the following is correct in               exchange of information
    increasing order of reliability of
    evidence?                                      [C] detection of adverse event–
                                                       exchange of information–
     [A] Case report < meta-analysis <                 separating signal from noise–
         randomized clinical trial <                   signal assessment–
         randomized     double   blind                 recommendation for action
         clinical trial
                                                   [D] detection of adverse event–
     [B] Case report < randomized                      recommendation for action–
         clinical trial < randomized                   separating signal from noise–
         double blind clinical trial <                 signal assessment– exchange of
         meta-analysis                                 information

     [C] Randomized clinical trial <
         case report < meta-analysis <         33. The Pharmacy Act was enacted in
         randomized     double   blind
         clinical trial                            [A] 1947

     [D] Randomized clinical trial <               [B] 1948
         randomized      double   blind
         clinical trial < case report <
                                                   [C] 1949
         meta-analysis
                                                   [D] 1950
31. In the Drugs and Cosmetics Act
    and Rules, which of the following
    schedule   contains     requirement        34. The     mean     and       mode   of
    and guidelines for clinical trials?            4,2,4,3,2,2,6,7 are

     [A] Schedule U                                [A] 4 and 2 respectively

     [B] Schedule X                                [B] 2 and 4 respectively

     [C] Schedule W                                [C] 3·15 and 2 respectively

     [D] Schedule Y                                [D] 3·75 and 2 respectively
Pharmacy/17-A                              6
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 7 of 16
Page 7 of 16
Text of page 7
35. The full form of CPCSEA is                  39. Which of the following nucleophiles
     [A] Committee for the Purpose of               assists    the    deprotection   of
         Culture and Supervision of                 trimethylsilyl ethers?
         Experiments on Animals                     [A] F –
     [B] Committee for the Purpose of
         Control   and    Study    of               [B] OH–
         Experiments on Animals                     [C] NH2–
     [C] Committee for the Purpose of
         Control and Supervision of                 [D] SH–
         Experiments on Animals
     [D] Committee for the Purpose of           40. In oxidation-reduction titrations,
         Control and Supervision of                 one mole of potassium dichromate
         Ethical work on Animals                    is equivalent to Fe of
                                                    [A] 1 mole
36. The first edition of the Indian
    Pharmacopoeia was published in                  [B] 2 moles
    independent India in
                                                    [C] 4 moles
     [A] 1947
                                                    [D] 6 moles
     [B] 1948
     [C] 1955
                                                41. Presence of lipopolysaccharides in
     [D] 1950                                       cell wall is a characteristic of
                                                    [A] fungi
37. Human plasma contains about
    5 mEq/liter of calcium ions. How                [B] algae
    many milligrams of calcium chloride
                                                    [C] gram +ve bacteria
    dihydrate, CaCl2·2H2O (molecular
    weight 147 g/mole), are required to             [D] gram –ve bacteria
    prepare 100 ml of a solution equal
    in Ca2+ to human plasma?                    42. Two bacteria most useful            in
     [A] 29·4                                       genetic engineering are
     [B] 73·5                                       [A] Rhizobium and Azotobacter
     [C] 27·56
                                                    [B] Rhizobium and Diplococcus
     [D] 36·75
                                                    [C] Nitrosomonas and Klebsiella
38. Which of the following is true for              [D] Escherichia and Agrobacterium
    any (S)-enantiomer?
     [A] It rotates plane-polarized light       43. Bilirubin is synthesized from
         to the right
     [B] It rotates plane-polarized light           [A] lipids
         to the left                                [B] bile
     [C] It is a racemic form
                                                    [C] WBC
     [D] It is the mirror image of the
         corresponding (R)-enantiomer               [D] RBC

Pharmacy/17-A                               7                                    [ P.T.O.
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 8 of 16
Page 8 of 16
Text of page 8
44. Maintaining    the   volume    and        48. Identify the antiemetic agent which
    composition of body fluids within a           is related to neuroleptics.
    narrow range is called
                                                  [A] Meclizine
     [A] rehydration
                                                  [B] Prochlorperazine
     [B] equilibrium
                                                  [C] Tropisetron
     [C] homeostasis                              [D] Nabilone

     [D] total body water
                                              49. Which of the following drugs inhibits
                                                  peristalsis?
45. Which of the following is an
    example of drug that directly                 [A] Loperamide
    inhibits renin?
                                                  [B] Bisacodyl
     [A] Enalapril
                                                  [C] Racecadotril
     [B] Captopril                                [D] Sorbitol

     [C] Aliskiren
                                              50. Which of the following statements
     [D] Losartan                                 is true about carbamazepine?

                                                  [A] It can be used in the treatment
46. Which of the following CCBs has                   of bipolar disorder, trigeminal
    most rapid onset of action after                  neuralgia and epilepsy
    oral administration?
                                                  [B] Like phenytoin, it enhances
     [A] Felodopine                                   GABA activity at therapeutic
                                                      concentrations
     [B] Verapamil
                                                  [C] It is an enzyme inhibitor
     [C] Nifedipine                               [D] It can cause a mild, but
                                                      persistent leukopenia and this
     [D] Diltiazem                                    is an indication to stop
                                                      treatment
47. Which     drug   is     an   analog
    prostaglandin E1?                         51. TNF- responds primarily to which
                                                  of the following?
     [A] Misoprostole
                                                  [A] Viral infection
     [B] De-nol
                                                  [B] Gram –ve bacteria
     [C] Sucralfate
                                                  [C] Gram +ve bacteria
     [D] Dinoprostone                             [D] Tumor growth
Pharmacy/17-A                             8
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 9 of 16
Page 9 of 16
Text of page 9
52. Which of the following cells does/          57. Lowering of which hormone causes
    do not contain DNA?                             menstruation in menstrual cycle?
     [A] An enucleated ovum                         [A] Estrogen
     [B] Hair root                                  [B] Thyroxin
     [C] Mature RBCs                                [C] Progesterone

     [D] A mature spermatozoa                       [D] Follicle stimulating hormone


53. Hemophilia-A occurs due to the              58. Change of state from a gas directly
    absence of which clotting factor?               to a solid is known as

     [A] Factor VIII                                [A] fusion

     [B] Factor VII                                 [B] boiling

     [C] Factor IX                                  [C] sublimation

     [D] Factor X                                   [D] deposition


54. Most   of   the    carbon    dioxide        59. Triple point of water corresponds to
    produced    in   the    tissues    is           [A] 600 N/m2 pressure and 0·0075 °C
    transported to the lungs as                         temperature
     [A] carbonates                                 [B] 610 N/m2 pressure and 0·0075 °C
                                                        temperature
     [B] bicarbonates
                                                    [C] 605 N/m2 pressure and 0·0075 °C
     [C] dissolved in the blood
                                                        temperature
     [D] attached to haemoglobin
                                                    [D] 610 N/m2 pressure and 0·0070 °C
                                                        temperature
55. During     tubular     reabsorption
    process, which ion is reabsorbed in         60. At    critical  temperature,     the
    exchange for sodium?                            surface tension of a liquid is
     [A] Potassium                                  [A] zero
     [B] Chloride                                   [B] one
     [C] Calcium                                    [C] negative
     [D] Magnesium                                  [D] maximum

56. A hormone secreted by kidney,               61. Increase in resistance to flow with
    that    stimulates  bone marrow                 increase in rate of shear is
    activity, is called                             referred to as
     [A] renin                                      [A] dilatancy
     [B] aldosterone                                [B] rheopaxy
     [C] somatomedin                                [C] thixotropy
     [D] erythropoietin                             [D] antithixotropy

Pharmacy/17-A                               9                                    [ P.T.O.
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 10 of 16
Page 10 of 16
Text of page 10
62. What     will    be    the    percent        66. The correct sequence of solvents
    elimination after 2 biological half-             when arranged in increasing order
    lives in first-order kinetics?                   of their polarity is

     [A] 50%                                         [A] hexane < chloroform < toluene
                                                         < ethyl acetate < methanol <
     [B] 55%                                             water

                                                     [B] toluene < hexane < ethyl
     [C] 65%
                                                         acetate < chloroform < water <
                                                         methanol
     [D] 75%
                                                     [C] hexane < toluene < chloroform
                                                         < ethyl acetate < methanol <
63. _____ makes an unabsorbable                          water
    complex with tetracycline.
                                                     [D] toluene < hexane < chloroform
     [A] Lactose                                         < ethyl acetate < water <
                                                         methanol
     [B] Dicalcium phosphate

     [C] Starch                                  67. Biogenetic precursor     for   indole
                                                     alkaloids is
     [D] Gelatine                                    [A] tryptophan

                                                     [B] phenylalanine
64. The distinctive signs that identify
    certain goods produced or provided               [C] tyrosine
    by a specific person or enterprise
    are known as                                     [D] glycine

     [A] copyright                               68. Which of the following oils is rich
                                                     in alcoholic compounds?
     [B] patent
                                                     [A] Fennel oil
     [C] geographical indications
                                                     [B] Chenopodium oil
     [D] trademark
                                                     [C] Spearmint oil

                                                     [D] Coriander oil
65. Which of the following is not
    an   element   of    non-verbal
    communication?                               69. Phenylpropanoids are biosynthesized
                                                     through _____ pathway.
     [A] Facial expression
                                                     [A] acetate-malonate
     [B] Eye contact
                                                     [B] acetate-mevalonate
     [C] Posture                                     [C] polyketide

     [D] A speech                                    [D] shikimic acid
Pharmacy/17-A                               10
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 11 of 16
Page 11 of 16
Text of page 11
70. A substance is known as             a         74. A patient suffering from vomiting
    supercritical fluid when it is                    due to cancer chemotherapy can
                                                      get relief from
     [A] above its critical point       of
         temperature and pressure                     [A] bromocriptine

     [B] below its critical point       of            [B] cimetidine
         temperature and pressure                     [C] ondansetron
     [C] at  its   critical point       of            [D] loratadine
         temperature and pressure
     [D] at room temperature          and         75. Thioridazine    was     withdrawn
         atmospheric pressure                         worldwide as its use causes
                                                      [A] constipation
71. The phenomena in which a drug                     [B] disturbed sleep cycles
    blocks the action of another drug
    by occupying its receptors without                [C] hormonal imbalance
    activating them is known as                       [D] cardiac arrhythmias
     [A] partial antagonism
                                                  76. Association,   commissural and
     [B] competitive antagonism                       projection tracts of axons are
     [C] chemical antagonism                          found in
                                                      [A] cerebral grey matter
     [D] non-competitive antagonism
                                                      [B] cerebral white matter
72. Which of the following classes of                 [C] basal ganglia
    drugs      are   approved     for
                                                      [D] epithalamus
    symptomatic treatment of memory
    disorders?
                                                  77. Groups    of   lymphatic  nodules
     [A] Calcium channel blockers                     present in the ileum region of
                                                      small intestine are known as
     [B] COX inhibitors
                                                      [A] Brunner’s glands
     [C] Acetylcholinesterase   inhibitors
                                                      [B] mucosa-associated      lymphoid
     [D] -blockers                                       tissue
                                                      [C] Paneth cells
73. A person is to be given digoxin to
    treat CHF. Which of the following                 [D] Peyer’s patches
    conditions is to be critically
    monitored before giving digoxin to            78. The pH of a buffer system can be
    avoid digoxin toxicity?                           calculated with the
     [A] Hypochloremia                                [A] Stokes equation

     [B] Hyponatremia                                 [B] Henderson-Hasselbalch
                                                                               equation
     [C] Hypocalcemia
                                                      [C] Michaelis-Menten    equation
     [D] Hypomagnesemia
                                                      [D] Young equation
Pharmacy/17-A                                11                                    [ P.T.O.
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 12 of 16
Page 12 of 16
Text of page 12
79. According to IP, a substance is                  83. Which of the following statements
    categorized as ‘sparing soluble’ if                  regarding HLB value of emulsifiers
    its                                                  is incorrect?
     [A] 40 parts are soluble in 100                     [A] Emulsifiers with HLB value of
         parts of the given solvent                          1·5 to 3·7 have high water
                                                             dispersibility
     [B] 20 parts are soluble in 100 parts
         of the given solvent                            [B] Emulsifiers with HLB value of
                                                             1·5 to 3·7 have low water
     [C] 30 parts are soluble in 100 parts                   dispersibility
         of the given solvent
                                                         [C] Emulsifiers with HLB value of
     [D] 50 parts are soluble in 100 parts                   13 to 20 have high water
         of the given solvent                                dispersibility
                                                         [D] Emulsifiers with HLB value of
80. Enteric coated        tablets   can    be                9·5 to 10·3 form stable milky
    coated with                                              dispersions
     [A] hydroxypropyl methyl cellulose
                                                     84. Reversible aggregation of droplets
     [B] polyethylene glycol
                                                         of internal phase is known as
     [C] cellulose acetate phthalate
                                                         [A] creaming
     [D] carboxymethyl cellulose                         [B] coalescence
                                                         [C] flocculation
81. Dissolution rate of a tablet           is
    calculated with the help of                          [D] phase separation
     [A] Stokes equation
                                                     85. Which of the following is a non-
     [B] Michaelis-Menten       equation                 ionic surfactant?
     [C] Young equation                                  [A] Polyoxyethylene sorbitan
                                                                                monooleate
     [D] Noyes-Whitney equation
                                                         [B] Dioctyl sulphosuccinate
82. Non-linear     pharmacokinetics       can            [C] Sodium pareth sulphate
    be due to
                                                         [D] Dioctadecyldimethyl
      (i) Induction of enzymes                                         ammonium bromide
     (ii) Active secretion
                                                     86. Leakers test, clarity test, pyrogen
     Which of the following is a correct                 test are the common quality
     statement?                                          control tests done for
     [A] (i) is true and (ii) is false                   [A] solutions
     [B] (i) is false and (ii) is true                   [B] parenteral products
     [C] Both (i) and (ii) are true                      [C] suppositories
     [D] Both (i) and (ii) are false                     [D] suspensions

Pharmacy/17-A                                   12
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 13 of 16
Page 13 of 16
Text of page 13
87. Major symptoms of Ehlers-Danlos               90. Biological activity of 0·05 µf     of
    syndrome,    which    is  due    to               cholecalciferol is equivalent to
    abnormality in gene for procollagen
    are                                               [A] 1 IU of vitamin D

     [A] stiff  joints  which     restrict            [B] 2 IU of vitamin D
         movements and dark, non-
         elastic skin that constricts                 [C] 3 IU of vitamin D
         peripheral blood vessels
                                                      [D] 0·5 IU of vitamin D
     [B] over-flexible   joints    which
         easily    get  dislocated  and
         highly elastic skin that easily          91. Neurological   manifestation       of
         get bruises                                  pernicious anemia is due to

                                                      [A] taurine
     [C] stiff joints and translucent
         highly elastic skin
                                                      [B] tyrosine

     [D] deformed bones and dark, non-                [C] xantherunic acid
         elastic skin
                                                      [D] phenylpyruvic acid

88. Phospholipids   are         important
    constituents of cell       membranes          92. Organic substance is salted out
    because they have                                 from its aqueous solution if

     [A] both polar      and    non-polar             [A] dielectric constant of solution
         groups                                           is less than that of pure water

                                                      [B] dielectric constant of solution
     [B] fatty acids
                                                          is more than that of pure
                                                          water
     [C] phosphoric acid
                                                      [C] dielectric constant of solution
     [D] glycerol                                         is equal to that of pure water

                                                      [D] None of the above
89. Rieske iron-sulphur proteins are
    found in _____ of ETC.
                                                  93. Milk of magnesia is used as
     [A] Complex I
                                                      [A] electrolyte

     [B] Complex II                                   [B] topical agent

     [C] Complex III                                  [C] astringent

     [D] Complex IV                                   [D] antacid

Pharmacy/17-A                                13                                     [ P.T.O.
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 14 of 16
Page 14 of 16
Text of page 14
94. A mixture is having the following           98. During the decarboxylation of
    group of compounds. Which is the                methylethylmalonic acid in the
    correct order, if these compounds               presence of brucine, the optically
    are arranged in decreasing order of             active 2-methylbutyric acid is
    the adsorption tendency on a silica             formed.      The       dextrorotatory
    column?                                         enantiomer is 10% less than the
                                                    levorotatory enantiomer. What is
      (i)    Acidic
                                                    the optical purity of the mixture?
      (ii)   Esters
                                                     [A] 10%
     (iii)   Carbonyl
                                                     [B] 90%
     (iv)    Alcoholic                               [C] 80%
      (v)    Hydrocarbons                            [D] 20%
     [A] (i) > (iv) > (iii) > (ii) > (v)
                                                99. Match the classes and the alkaloids
     [B] (iv) > (iii) > (i) > (v) > (ii)
                                                    given below :
     [C] (v) > (ii) > (i) > (iii) > (iv)
                                                  Class of Alkaloid            Alkaloid
     [D] (iii) > (v) > (ii) > (iv) > (i)
                                                   (i) Tropane             P. Reserpine
                                                   (ii) Indole             Q. Scopolamine
95. Lag phase, exponential phase,
    declined    growth    phase   and             (iii) Quinoline          R. Codeine
    stationary phase are found in
                                                  (iv) Phenanthrene        S. Cinchonine
     [A] suspension culture
                                                     [A] (i)–R, (ii)–Q, (iii)–P, (iv)–S
     [B] callus culture
                                                     [B] (i)–Q, (ii)–P, (iii)–S, (iv)–R
     [C] protoplast culture
                                                     [C] (i)–S, (ii)–Q, (iii)–R, (iv)–P
     [D] hairy root culture
                                                     [D] (i)–Q, (ii)–S, (iii)–R, (iv)–P

96. To     visualize   DNA     in   gel
    electrophoresis _____ dye is used.          100. The following structure              is   the
                                                     basic nucleus of
     [A] ethylene bromide
     [B] methylene bromide
     [C] ethidium bromide
     [D] phosphorothioate

97. Good manufacturing practices for
    AYUSH drugs are covered under
     [A] Schedule M                                  [A] flavone
     [B] Schedule U                                  [B] flavanone
     [C] Schedule T                                  [C] neoflavone
     [D] Schedule Y                                  [D] isoflavone
Pharmacy/17-A                              14
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 15 of 16
Page 15 of 16
Text of page 15
SPACE FOR ROUGH WORK




Pharmacy/17-A            15            [ P.T.O.
HPSC Polytechnic Lecturer 2022 question paper, Lecturer (Technical Education) Screening Test, Pharmacy (Advt. No. 11/2021), page 16 of 16
Page 16 of 16
Text of page 16
SPACE FOR ROUGH WORK




                       
Pharmacy/17-A            16            LLL22/17—123×4
Page 1 of 16

Source: Haryana Public Service Commission. Question paper published by Haryana Public Service Commission.

Other years