Transition from Metaphase to Anaphase involves activation of Anaphase Promoting Complex (APC) by .....................
MH SET - 2025, SET Exam - 2025,
Answer: A
The APC is activated by CDC20.
At the metaphase to anaphase transition, once every kinetochore is attached and the spindle checkpoint is satisfied, Cdc20 binds and activates the anaphase-promoting complex. APC/C-Cdc20 ubiquitinates securin and cyclin B, freeing separase to cut cohesin so that sister chromatids separate.
Cdc25 is the phosphatase that activates CDK1 at the G2 to M transition. Cdc18 (the fission yeast relative of Cdc6) helps load the replication machinery for S phase. Cdc13 is the B-type cyclin of fission yeast. None of them activates the APC.
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