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Extensions of Mendelism Questions and Answers

1.

Human ABO blood group system is the example of

Exam Year(s)

MPPSC Forest Service - 2023,

Answer: B

The ABO system is an example of multiple alleles.

A single gene, I, controls the ABO blood groups, and it has three alleles in the population: \(I^A\), \(I^B\) and i. Any person carries only two of them, but the existence of more than two alternative forms of one gene is what multiple allelism means. \(I^A\) and \(I^B\) are also codominant.

Epistasis and complementation involve interactions between two different genes, and polygenic inheritance involves many genes acting together on a continuous trait such as height.

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Answer: A

The difference is that in Drosophila the ratio of X chromosomes to autosomes decides sex, whereas in humans the Y chromosome determines maleness.

In Drosophila an X:A ratio of 1 (XX with two sets of autosomes) gives a female and a ratio of 0.5 gives a male, so an XO fly is a (sterile) male and an XXY fly is a female; the Y is needed only for male fertility. In humans the SRY gene on the Y chromosome switches on testis development, so XXY (Klinefelter) individuals are male and XO (Turner) individuals are female.

The other options reverse the two systems: a mere pair of X chromosomes does not decide sex in the fly, the Y does not determine maleness in Drosophila, and a single X without a Y gives a female, not a male, in humans.

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3.

The phenotypic ratio obtained in F2 is 2 : 1 in the progeny of cross due to presence of :

Exam Year(s)

MH SET - 2018, SET Exam - 2018,

Answer: C

A 2 : 1 ratio is due to a lethal allele.

Crossing two heterozygotes normally gives 1 AA : 2 Aa : 1 aa. If the allele is lethal when homozygous, one class dies before it can be counted, and the survivors appear in a 2 : 1 ratio. The classic case is the yellow coat allele AY in mice (Cuenot): yellow x yellow gives 2 yellow : 1 non-yellow, because AYAY embryos die.

A plain dominant allele gives 3 : 1, a recessive one also 3 : 1, and a co-dominant (or incompletely dominant) one 1 : 2 : 1. Only lethality removes a class and leaves 2 : 1.

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4.

In a hypothetical diploid animal species, there is a locus with two alleles A and B. If A and B are co-dominant, then how many different phenotypes are possible in this species ?

Exam Year(s)

MH SET - 2021, SET Exam - 2021,

Answer: C

3 phenotypes are possible.

With two alleles at one locus there are three genotypes: AA, AB and BB. When the alleles are co-dominant, both are fully expressed in the heterozygote, so AB shows the products of both A and B and looks different from either homozygote. Each genotype therefore has its own phenotype:

\[ \text{AA},\ \text{AB},\ \text{BB}: 3\ \text{phenotypes} \]

Two phenotypes would be the result with complete dominance, where AB looks like one homozygote. Four would need a third allele or a second locus.

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